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Physiological iron deficiency is typically linked to increased demand and inadequate absorption, while pathological iron deficiency may arise from iron malabsorption (such as gastric acid insufficiency or mutations in TMPRSS6 ) or chronic blood loss (due to tumours, gastrointestinal bleeding, or infections), among other causes [61–64]

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In a study evaluating more than 46,000 kidney transplant recipients, female recipients experienced less delayed graft function than male recipients, highlighting the protective environment of female kidneys in humans